Criteria for Engineering Cutinases: Bioinformatics Analysis of Catalophores
نویسندگان
چکیده
Cutinases are bacterial and fungal enzymes that catalyze the hydrolysis of natural cutin, a three-dimensional inter-esterified polyester with epoxy-hydroxy fatty acids chain lengths between 16 18 carbon atoms. Due to their ability accept long substrates, cutinases also effective in catalyzing vitro both degradation synthesis several synthetic polyesters polyamides. Here, we present bioinformatics study intends correlate structural features catalytic properties provide rational basis for exploitation, particularly polymer biodegradation. The used BioGPS method (Global Positioning System Biological Space) computed molecular descriptors based on Molecular Interaction Fields (MIFs) described GRID force field. information was generate catalophores, spatial representations each enzymatic active site establish hydrophobic electrostatic interactions. These tools were exploited comparing other serine-hydrolases enzymes, namely lipases, esterases, amidases proteases, highlighting differences similarities might guide engineering strategies. Structural correlated. “catalophore” indicate shared lipases esterases.
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ژورنال
عنوان ژورنال: Catalysts
سال: 2021
ISSN: ['2073-4344']
DOI: https://doi.org/10.3390/catal11070784